Gastroesophagopharyngeal acid reflux
Viewed 484 times
-
Prevalence of gastroesophagopharyngeal acid reflux events
Abstract Objectives To identify variables contributing to discrepant gastroesophagopharyngeal acid reflux (GEPR) findings and to critically assess the prevalence of GEPR in healthy individuals and patients with reflux laryngitis (RL). Study design Quantitative systematic review. Methods Pharyngeal pH monitoring studies of healthy individuals and patients with RL were identified through a MEDLINE search of publications between 1966 and 2003. Pooled results of the measured pharyngeal acid exposure characteristics and the prevalence of GEPR events were analyzed. Statistical comparisons were performed using a chi 2 test. Results The study included 181 controls and 184 RL patients. Subjects' age ranged from 19 to 85 years. Gastroesophagopharyngeal acid reflux events were detected at 1, 2, and 4 cm above upper esophageal sphincter (UES) and 0.5 cm below arytenoids, with varying rates. The prevalence of GEPR ranged from 0% to 83% in controls and 27% to 86% in RL. After excluding the healthy subjects with abnormal esophageal acid exposure, prevalence of GEPR decreased from 35% to 17% ( P Ulualp SO, Roland PS, Toohill RJ, Shaker R.
1: Am J Otolaryngol. 2005 Jul-Aug;26(4):239-44. Related Articles, Links
